Investigating metabolic changes in the eye during bacterial and fungal infections
Vitreous metabolic perturbations during bacterial and fungal endophthalmitis
This study is looking at how infections in the eye can change its metabolism, especially in people with endophthalmitis, to find new ways to diagnose and treat the condition better, ultimately helping to improve care for patients and their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10990855 on NIH RePORTER |
What this research studies
This research focuses on understanding how bacterial and fungal infections affect the metabolism of the eye, specifically in cases of endophthalmitis, which can lead to severe vision loss. The study aims to identify biomarkers through metabolomics, a technology that analyzes small biochemical compounds in the body, to improve diagnosis and treatment. By comparing metabolic profiles from infected and uninfected eyes, the researchers hope to uncover new therapeutic targets and enhance patient care. This approach could lead to more effective antimicrobial therapies tailored to individual patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing symptoms of endophthalmitis or those diagnosed with uveitis and other inflammatory eye conditions.
Not a fit: Patients with non-infectious eye conditions or those who do not exhibit symptoms of endophthalmitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted treatments for patients suffering from endophthalmitis, potentially preserving their vision.
How similar studies have performed: Previous research has shown promise in using metabolomics for identifying biomarkers in various diseases, suggesting that this approach could yield valuable insights in the context of endophthalmitis.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Kumar, Ashok — Wayne State University
- Study coordinator: Kumar, Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.