Investigating metabolic changes in the eye during bacterial and fungal infections
Official title: Vitreous metabolic perturbations during bacterial and fungal endophthalmitis
Funded at Wayne State University · NIH-10990855 · Data updated 2026-11-12
This study is looking at how infections in the eye can change its metabolism, especially in people with endophthalmitis, to find new ways to diagnose and treat the condition better, ultimately helping to improve care for patients and their vision.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $487,174 |
| NIH project number | 1R01EY035499-01A1 |
| Project ID | NIH-10990855 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing symptoms of endophthalmitis or those diagnosed with uveitis and other inflammatory eye conditions.
✕Less likely to help
Patients with non-infectious eye conditions or those who do not exhibit symptoms of endophthalmitis may not benefit from this research.
What this research studies
This research focuses on understanding how bacterial and fungal infections affect the metabolism of the eye, specifically in cases of endophthalmitis, which can lead to severe vision loss. The study aims to identify biomarkers through metabolomics, a technology that analyzes small biochemical compounds in the body, to improve diagnosis and treatment. By comparing metabolic profiles from infected and uninfected eyes, the researchers hope to uncover new therapeutic targets and enhance patient care. This approach could lead to more effective antimicrobial therapies tailored to individual patients.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted treatments for patients suffering from endophthalmitis, potentially preserving their vision.
How similar studies have gone: Previous research has shown promise in using metabolomics for identifying biomarkers in various diseases, suggesting that this approach could yield valuable insights in the context of endophthalmitis.
Where this research is happening
-
Wayne State University
Detroit, United States Active
Researchers
- Principal investigator: Kumar, Ashok — Wayne State University
- Study coordinator: Kumar, Ashok
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.