Investigating metabolic changes in polycystic kidney disease using advanced imaging techniques
Metabolic imaging of hyperpolarized 13C pyruvate in polycystic kidney disease
This study is exploring new ways to use special imaging technology to see how metabolism changes in people with autosomal dominant polycystic kidney disease (ADPKD), which could help us find better treatments for the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10690724 on NIH RePORTER |
What this research studies
This research focuses on developing new imaging tools to study metabolic changes in patients with autosomal dominant polycystic kidney disease (ADPKD). By utilizing hyperpolarized 13C MR spectroscopy, the study aims to measure metabolic processes in real-time and in a non-invasive manner. This approach seeks to enhance our understanding of how altered metabolism contributes to the disease, potentially leading to new therapeutic targets. The research addresses a significant gap in current methodologies that typically rely on laboratory assays rather than in vivo measurements.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of polycystic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for patients suffering from polycystic kidney disease.
How similar studies have performed: Previous research has shown promise in using metabolic imaging techniques for other diseases, suggesting potential success for this novel approach in PKD.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Mayer, Dirk — University of Maryland Baltimore
- Study coordinator: Mayer, Dirk
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.