Investigating megesterol to help children with feeding difficulties transition from tube to oral eating
The safety and efficacy of megesterol as part of an outpatient feeding protocol for children with chronic medical conditions
This study is looking at whether a medication called megesterol can help children who have chronic medical conditions and currently rely on feeding tubes to start eating by mouth again, using a special program designed to support them in this transition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kansas Medical Center NIH-funded |
| Lab location | 1 site (Kansas City, United States) |
| Project ID | NIH-10642653 on NIH RePORTER |
What this research studies
This research focuses on helping children with chronic medical conditions who struggle with feeding, particularly those who rely on gastrostomy or gastrojejunal tube feeding. The study evaluates the safety and effectiveness of megesterol, a medication, as part of an outpatient protocol designed to transition these children from tube feeding to oral eating. The approach involves a randomized controlled trial comparing megesterol to a placebo, aiming to determine if it can significantly improve oral intake in these children. By utilizing an interdisciplinary outpatient protocol called iKanEat, the research seeks to provide a more effective solution for children facing long-term feeding challenges.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 years who have chronic medical conditions and require tube feeding.
Not a fit: Patients who do not have feeding difficulties or those who are not reliant on tube feeding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enable children with chronic medical conditions to transition to oral eating, improving their nutritional intake and quality of life.
How similar studies have performed: Previous research has shown success with similar outpatient feeding protocols, indicating potential for this approach to be effective.
Where this research is happening
Kansas City, United States
- University of Kansas Medical Center — Kansas City, United States (Active)
Researchers
- Principal investigator: Davis, Ann M — University of Kansas Medical Center
- Study coordinator: Davis, Ann M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.