Investigating medications to prevent breast cancer in childhood cancer survivors
Can risk-reducing medications improve breast cancer prevention in childhood and adolescent cancer survivors? Comparative modeling to inform care
This study is looking at ways to help childhood and adolescent cancer survivors lower their chances of getting breast cancer by testing medications that could cut that risk in half, so they can enjoy better long-term health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10892277 on NIH RePORTER |
What this research studies
This research focuses on childhood and adolescent cancer survivors who are at high risk for developing breast cancer due to previous treatments. It aims to evaluate the effectiveness of risk-reducing medications, such as selective estrogen receptor modulators and aromatase inhibitors, which could potentially lower the risk of breast cancer by 50%. The study uses simulation modeling and observational data to inform clinical care and improve adherence to preventive measures. By understanding the impact of these medications, the research seeks to enhance the long-term health outcomes of these survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are female survivors of childhood or adolescent cancer who have received chest radiation or high doses of anthracycline chemotherapy.
Not a fit: Patients who have not undergone treatment for childhood or adolescent cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the incidence of breast cancer among childhood cancer survivors.
How similar studies have performed: Other research has shown promising results with similar risk-reducing medications in high-risk populations, indicating potential for success in this area.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Yeh, Jennifer M. — Boston Children's Hospital
- Study coordinator: Yeh, Jennifer M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.