Investigating mechanisms of colorectal and lung cancer
Official title: BLRD Research Career Scientist Award Application
Funded at Birmingham VA Medical Center · NIH-11101257 · Data updated 2026-11-12
This study is looking into how certain proteins and pathways in the body affect the growth of colorectal and lung cancer, especially how they make it harder for treatments to work, and it’s for anyone interested in understanding more about cancer and how smoking might play a role in its development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| NIH project number | 5IK6BX006029-04 |
| Project ID | NIH-11101257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with colorectal or lung cancer, particularly those who may be resistant to current treatments.
✕Less likely to help
Patients with cancers other than colorectal or lung cancer may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the biological mechanisms behind colorectal and lung cancer, particularly how certain proteins and signaling pathways contribute to cancer progression and treatment resistance. Dr. Pran K. Datta, a leading expert in cancer research, utilizes advanced techniques to study the role of specific proteins, such as STRAP, in cancer stem cells and their response to therapies. The research also explores the impact of smoking on cancer development through the identification of specific microRNA signatures. By collaborating with various institutions, this work aims to enhance our understanding of cancer biology and improve treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets and strategies for treating colorectal and lung cancer more effectively.
How similar studies have gone: Previous research in cancer biology has shown success in identifying key mechanisms that lead to improved treatment outcomes, suggesting that this approach has the potential for significant advancements.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Datta, Pran K — Birmingham VA Medical Center
- Study coordinator: Datta, Pran K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.