Investigating M1 Aminopeptidases and their role in Alzheimer's Disease
Structural and Bioinformatics Analyses of M1 Aminopeptidases
This study is looking at certain enzymes that play a role in Alzheimer's disease to find better ways to create treatments that work well without causing unwanted side effects.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Massachusetts Lowell NIH-funded |
| Lab location | 1 site (Lowell, United States) |
| Project ID | NIH-10437967 on NIH RePORTER |
What this research studies
This research focuses on understanding the structure and function of M1 aminopeptidases, specifically ERAP1 and IRAP, which are enzymes involved in various biological processes and diseases, including Alzheimer's Disease. The researchers aim to explore how these enzymes can be targeted for therapeutic purposes while minimizing side effects caused by off-target interactions. By analyzing the catalytic domains of these enzymes, the study seeks to develop more effective inhibitors that could potentially improve treatment options for patients with Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's Disease or related dementias.
Not a fit: Patients with other forms of dementia not related to Alzheimer's may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with Alzheimer's Disease.
How similar studies have performed: Previous research has shown promise in targeting M1 aminopeptidases for therapeutic interventions in various diseases, indicating a potential for success in this approach.
Where this research is happening
Lowell, United States
- University of Massachusetts Lowell — Lowell, United States (Active)
Researchers
- Principal investigator: Guo, Hwai-Chen — University of Massachusetts Lowell
- Study coordinator: Guo, Hwai-Chen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.