Investigating lung transplant complications and potential treatments
Official title: Mitochondrial integrated stress response and lung allograft dysfunction
Funded at Northwestern University at Chicago · NIH-10933926 · Data updated 2026-11-12
This study is looking at how lung damage happens after a transplant and aims to find ways to help heal the lungs and prevent further problems, using advanced techniques to understand the cells better, so that we can create better treatments for lung transplant patients.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 17, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $458,632 |
| NIH project number | 1P01HL169188-01A1 |
| Project ID | NIH-10933926 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who have undergone lung transplantation and are experiencing or at risk for chronic lung allograft dysfunction.
✕Less likely to help
Patients who have not received a lung transplant or those with other unrelated lung conditions may not benefit from this research.
What this research studies
This research focuses on understanding chronic lung allograft dysfunction (CLAD), a common and serious complication in lung transplant recipients. It explores how injury to lung cells leads to fibrosis and aims to identify ways to promote healing and prevent further damage. The study utilizes advanced techniques like single-cell RNA sequencing to analyze lung cells and their responses to stress. By investigating specific genes and pathways involved in lung injury, the research seeks to develop targeted therapies that could improve lung transplant outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for lung transplant recipients, potentially reducing the incidence of chronic lung allograft dysfunction.
How similar studies have gone: Previous research has shown promise in understanding lung fibrosis and the role of specific genes, indicating that this approach could lead to meaningful advancements in treatment.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Han, Seunghye — Northwestern University at Chicago
- Study coordinator: Han, Seunghye
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.