Investigating lung repair mechanisms after chlorine and phosgene inhalation injuries
Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries
This study is looking at how breathing in harmful chemicals like chlorine and phosgene affects lung cells, which are important for keeping our lungs healthy and healing them when they're hurt, and it's designed to help find new treatments for lung injuries caused by these toxins.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10912691 on NIH RePORTER |
What this research studies
This research explores how inhalation of harmful chemicals like chlorine and phosgene affects different types of lung cells, which are crucial for maintaining healthy lung function and repairing damage. By using rodent and pig models, the study aims to understand the specific cellular responses and repair mechanisms that occur after exposure to these chemicals. The researchers will monitor the changes in lung cell populations over time to identify potential new treatments for lung injuries caused by these toxic agents.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced lung injuries due to chlorine or phosgene exposure, whether from accidents or other incidents.
Not a fit: Patients with lung injuries caused by other non-chemical factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance lung repair and improve recovery for patients affected by chemical inhalation injuries.
How similar studies have performed: While the specific mechanisms being investigated are novel, previous research has shown promise in understanding lung repair processes in response to various injuries.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Jordt, Sven-Eric — Duke University
- Study coordinator: Jordt, Sven-Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.