Investigating lung injury and disease after tuberculosis in patients with and without HIV
Official title: Interleukin-6 signaling, lung injury, and post-TB lung disease in TB-HIV
Funded at Boston University Medical Campus · NIH-10924557 · Data updated 2026-11-12
This study is looking at how tuberculosis affects lung health in people who also have HIV, to better understand the long-term lung problems they might face after treatment, and it’s designed for patients who have experienced TB, with or without HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $743,698 |
| NIH project number | 1R01AI184179-01 |
| Project ID | NIH-10924557 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults aged 21 and older who have been diagnosed with drug-sensitive tuberculosis, especially those who are also HIV-positive.
✕Less likely to help
Patients who do not have a history of tuberculosis or who are not HIV-positive may not benefit from this research.
What this research studies
This research focuses on understanding how tuberculosis (TB) affects lung health, particularly in patients who are also living with HIV. It aims to identify the severity and characteristics of post-TB lung disease (PTLD) by comparing TB patients with and without HIV. The study will involve detailed assessments of lung function and overall health during and after TB treatment, using a multi-dimensional approach. By leveraging existing research networks, the project seeks to gather comprehensive data to inform future interventions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing lung injury and improving health outcomes for TB survivors, particularly those co-infected with HIV.
How similar studies have gone: Previous research has shown promising results in understanding lung injury in TB patients, but this specific approach focusing on the interplay with HIV is relatively novel.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Gupte, Akshay Nitin — Boston University Medical Campus
- Study coordinator: Gupte, Akshay Nitin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.