Investigating lung inflammation caused by alcohol and marijuana use in adolescents
Official title: Pulmonary Disfunction after Polysubstance Exposure: Mechanistic Identification of Inflammatory Mediators
Funded at North Carolina Central University · NIH-10849893 · Data updated 2026-11-12
This study is looking at how using both alcohol and marijuana together might harm lung health in young people, and it's trying to find ways to help protect their lungs from these effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina Central University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | July 8, 2022 |
| Project end | November 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $150,000 |
| NIH project number | 5SC2GM144188-03 |
| Project ID | NIH-10849893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents and young adults who have a history of alcohol and marijuana use.
✕Less likely to help
Patients who do not use alcohol or marijuana, or those with pre-existing severe lung conditions unrelated to substance use, may not benefit from this research.
What this research studies
This research focuses on understanding how the combined use of alcohol and marijuana affects lung health, particularly in adolescents. By using a mouse model, the study examines the mechanisms behind increased lung inflammation and injury due to these substances. Researchers are exploring the role of specific receptors in the lungs that may be targeted for therapeutic interventions. The goal is to identify potential treatments that could mitigate the harmful effects of polysubstance exposure on lung function.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that protect lung health in adolescents who use alcohol and marijuana.
How similar studies have gone: Previous research has shown that targeting specific receptors can reduce inflammation in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
North Carolina Central University
Durham, United States Active
Researchers
- Principal investigator: Sivaraman, Vijay — North Carolina Central University
- Study coordinator: Sivaraman, Vijay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.