Investigating lung inflammation and fibrosis in tuberculosis patients
Inflammation and Fibrosis in Pulmonary TB: the INFIN-TB Study
This study is looking at how lung inflammation and scarring affect people who have survived tuberculosis, especially those living with HIV, to find ways to help prevent long-term lung problems after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10868574 on NIH RePORTER |
What this research studies
This research focuses on understanding how inflammation and fibrosis in the lungs affect individuals who have survived tuberculosis (TB), particularly those with HIV. The study aims to identify biological pathways that contribute to post-TB lung disease (PTLD) by enrolling a cohort of 250 participants, half of whom are HIV-positive and half HIV-negative. By examining the role of neutrophilic inflammation and profibrotic activity during TB treatment, the researchers hope to uncover potential interventions that could prevent or mitigate chronic lung issues. This research is crucial as it addresses a significant gap in knowledge regarding the long-term effects of TB on lung health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 21 and older who have recently been diagnosed with drug-susceptible pulmonary TB, particularly those with or without HIV.
Not a fit: Patients who have not been diagnosed with pulmonary TB or those with other chronic lung diseases unrelated to TB may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent chronic lung disease in TB survivors, improving their quality of life.
How similar studies have performed: Previous research has indicated that addressing inflammation during TB treatment may reduce the risk of developing PTLD, suggesting that this approach has potential for success.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Auld, Sara — Emory University
- Study coordinator: Auld, Sara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.