Investigating lung health after tuberculosis treatment
Official title: Phenotype, Progression and Immune Correlates of Post-Tuberculosis Lung Disease
Funded at Boston University Medical Campus · NIH-10821458 · Data updated 2026-11-12
This study is looking at how having pulmonary tuberculosis (PTB) can affect your lung health in the long run, even after you've finished treatment, and it's for people who have successfully completed their TB therapy.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 5, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $239,666 |
| NIH project number | 5R00AI151094-04 |
| Project ID | NIH-10821458 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have successfully completed treatment for pulmonary tuberculosis.
✕Less likely to help
Patients who have not been treated for tuberculosis or those with pre-existing chronic lung diseases unrelated to tuberculosis may not benefit from this research.
What this research studies
This research focuses on understanding the long-term effects of pulmonary tuberculosis (PTB) on lung function, particularly how lung injury can persist even after successful treatment. The study aims to identify different patterns of lung disease that may arise in patients who have had PTB, including chronic obstructive pulmonary disease (COPD) and other airflow limitations. By measuring immune markers and lung function in patients, the research seeks to uncover the underlying mechanisms that contribute to these conditions and explore potential therapeutic strategies. Patients who have completed TB therapy will be closely monitored to assess their lung health over time.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients suffering from chronic lung issues following tuberculosis.
How similar studies have gone: While the specific focus on post-tuberculosis lung disease is relatively novel, similar studies have shown success in understanding chronic lung conditions following other respiratory infections.
Where this research is happening
-
Boston University Medical Campus
Boston, United States Active
Researchers
- Principal investigator: Gupte, Akshay Nitin — Boston University Medical Campus
- Study coordinator: Gupte, Akshay Nitin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.