Investigating lung development issues in individuals with Down syndrome
Type I IFN signaling during lung development in Down Syndrome
This study is looking at how Down syndrome impacts lung development, especially how certain signals in the body might affect lung structure from before birth, to help us understand and improve breathing problems that people with Down syndrome often face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center NIH-funded |
| Lab location | 1 site (Torrance, United States) |
| Project ID | NIH-11042340 on NIH RePORTER |
What this research studies
This research focuses on understanding how Down syndrome affects lung development, particularly looking at the role of type I interferon signaling. Researchers will examine lung tissues from individuals with Down syndrome to identify structural abnormalities that may begin during fetal development. By analyzing gene expression and lung structure, the study aims to uncover the mechanisms behind respiratory issues commonly seen in both children and adults with Down syndrome. This could lead to better understanding and potential interventions for lung-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Down syndrome, particularly those experiencing respiratory issues.
Not a fit: Patients without Down syndrome or those who do not have any lung-related complications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for lung diseases in individuals with Down syndrome.
How similar studies have performed: Previous research has shown promising results in understanding lung development in other genetic conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
Torrance, United States
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center — Torrance, United States (Active)
Researchers
- Principal investigator: Danopoulos, Soula Athanasia — Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
- Study coordinator: Danopoulos, Soula Athanasia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.