Investigating lung cancer risks in people with and without HIV in East Africa
Molecular determinants of lung cancer in HIV infected and uninfected individuals in Uganda and Tanzania
This study is looking at how certain genes and changes in the body might affect the risk of lung cancer in people with HIV compared to those without, especially as they get older, to help find ways to predict who might develop lung cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10904979 on NIH RePORTER |
What this research studies
This research focuses on understanding the molecular factors that contribute to lung cancer in individuals infected with HIV compared to those who are not. It aims to identify specific genetic mutations associated with lung cancer and how these may differ based on HIV subtype. The study will also explore the role of aging and DNA changes in increasing lung cancer risk, particularly in HIV-positive patients. By analyzing these factors, the research seeks to develop potential biomarkers that could help predict lung cancer development in these populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living in East Africa who are either HIV-positive or HIV-negative and at risk for lung cancer.
Not a fit: Patients who do not reside in East Africa or those who do not have a risk of lung cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting and preventing lung cancer in individuals with HIV.
How similar studies have performed: Previous research has shown promising results in understanding cancer risks associated with HIV, but this specific approach focusing on molecular determinants in East Africa is relatively novel.
Where this research is happening
Cleveland, United States
- Case Western Reserve University — Cleveland, United States (Active)
Researchers
- Principal investigator: Gerson, Stanton L. — Case Western Reserve University
- Study coordinator: Gerson, Stanton L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.