Investigating lung cancer in Black Americans using tailored organoid systems
Official title: Full Project 2 - An Organoid System Tailored to Study Lung Cancer in Blacks
Funded at Florida Agricultural and Mechanical Univ · NIH-10931529 · Data updated 2026-11-12
This study is looking at lung cancer in Black men to find out why they are at higher risk, even if they don't smoke as much, by exploring their unique genetics and how it affects their cancer, with the goal of creating better treatments just for them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Agricultural and Mechanical Univ NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project start | September 19, 2018 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $84,523 |
| NIH project number | 5U54CA233396-07 |
| Project ID | NIH-10931529 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Black individuals diagnosed with lung adenocarcinoma or those at high risk for developing this type of cancer.
✕Less likely to help
Patients who do not identify as Black or who have other types of lung cancer may not receive benefits from this research.
What this research studies
This research focuses on understanding lung cancer, particularly in Black men, who are at a higher risk despite lower exposure to traditional risk factors like cigarette smoke. The project aims to identify genetic differences that contribute to lung adenocarcinoma (LUAD) in Black Americans by developing in vitro organoid models that accurately reflect these genetic backgrounds. By characterizing the unique cancer driver mutations and responses to therapies, the research seeks to improve treatment options specifically for this population. Patients may benefit from targeted therapies that are more effective based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for lung cancer in Black Americans.
How similar studies have gone: While there is ongoing research into lung cancer disparities, this specific approach using tailored organoid systems for Black Americans is relatively novel and has not been extensively tested.
Where this research is happening
-
Florida Agricultural and Mechanical Univ
Tallahassee, United States Active
Researchers
- Principal investigator: Lamango, Nazarius Saah — Florida Agricultural and Mechanical Univ
- Study coordinator: Lamango, Nazarius Saah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.