Investigating long-term symptoms of Lyme disease after treatment

A Prospective Study of Persistent Symptoms of Lyme Disease

NIH-funded research Tufts University Boston · NIH-10862287

This study is looking at why some people still feel unwell after being treated for Lyme disease, and it's for anyone who has had Lyme disease and wants to help researchers find better ways to understand and treat these lingering symptoms.

Quick facts

Grant typeP01 program project
Study typeNIH-funded research
Funding institutionTufts University Boston NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-10862287 on NIH RePORTER

What this research studies

This research focuses on understanding post-treatment Lyme disease syndrome (PTLDS) by enrolling patients diagnosed with acute Lyme disease and following them over time. The study aims to explore the multifactorial causes of PTLDS, including immune responses and bacterial characteristics, through a collaborative approach involving various specialists. By collecting data from patients throughout their recovery process, the researchers hope to gain insights that could lead to better diagnostic and treatment options for those affected by PTLDS.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals diagnosed with acute Lyme disease who are willing to participate in long-term follow-up.

Not a fit: Patients who have not been diagnosed with Lyme disease or those who do not experience persistent symptoms after treatment may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and management of persistent Lyme disease symptoms, ultimately enhancing patient care.

How similar studies have performed: While there have been previous studies on Lyme disease, this approach of prospective follow-up from acute diagnosis is novel and aims to fill gaps left by earlier research.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.