Investigating long-term oral health outcomes in patients with chronic graft-versus-host disease.
Long Term Oral Health Outcomes in the Chronic GVHD Consortium
This study is looking at the oral health problems that people face after receiving a stem cell transplant and developing chronic graft-versus-host disease, so we can better understand issues like mouth sores and dry mouth, and help improve their dental care and overall quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10664053 on NIH RePORTER |
What this research studies
This research focuses on understanding the oral health challenges faced by patients who have undergone allogeneic hematopoietic cell transplantation and developed chronic graft-versus-host disease (cGVHD). It aims to identify the prevalence of oral complications such as mucosal lesions, reduced saliva production, and jaw stiffness, which can lead to significant dental issues. By analyzing a large cohort of patients, the study seeks to establish evidence-based guidelines for managing oral health in these individuals, ultimately improving their quality of life. The research will involve collaboration between leading cancer research institutions to gather comprehensive data on tooth loss and oral health-related quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received allogeneic hematopoietic cell transplantation and are experiencing symptoms of chronic graft-versus-host disease.
Not a fit: Patients who have not undergone allogeneic hematopoietic cell transplantation or do not have chronic graft-versus-host disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved oral health management strategies for patients with chronic graft-versus-host disease, enhancing their overall quality of life.
How similar studies have performed: Previous research has shown that addressing oral health issues in transplant patients can lead to better overall health outcomes, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Treister, Nathaniel S — Brigham and Women's Hospital
- Study coordinator: Treister, Nathaniel S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.