Investigating long-term islet function after total pancreatectomy with islet autotransplantation
Long-Term Islet Function and Impact after Total Pancreatectomy with Islet Autotransplant (LIFT)
This study is looking at people who have had surgery to remove their pancreas and then had their insulin-producing cells put back in, to see how well those cells work over time and how it affects their blood sugar and diabetes, so we can find better ways to help them manage their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11015007 on NIH RePORTER |
What this research studies
This research focuses on patients who have undergone total pancreatectomy with islet autotransplantation (TPIAT) to alleviate severe pain from chronic pancreatitis. It aims to understand how well the islet cells function over the long term and how this affects blood sugar control and diabetes complications. By studying patients 5 to 20 years after their surgery, the research will explore the relationship between changes in gut anatomy, hormone levels, and islet function. The findings could help improve patient care and inform treatment decisions regarding islet autotransplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have had a total pancreatectomy with islet autotransplantation due to chronic pancreatitis.
Not a fit: Patients who have not undergone total pancreatectomy or those with other forms of diabetes unrelated to islet function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management of diabetes and improved quality of life for patients who have undergone TPIAT.
How similar studies have performed: While some studies have explored aspects of islet function post-transplant, this research aims to fill significant gaps in understanding long-term outcomes, making it a novel approach.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Bellin, Melena D. — University of Minnesota
- Study coordinator: Bellin, Melena D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.