Investigating long noncoding RNAs in brain development and disorders
Functional long noncoding RNAs in neural development
This study is looking at a special type of RNA called Pnky to see how it helps in brain development and how it might be linked to conditions like Alzheimer's, so we can better understand these diseases and find new ways to help people affected by them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10880527 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of long noncoding RNAs (lncRNAs) in the development of the brain and their implications in neurological disorders such as Alzheimer's disease. The researchers are using molecular-genetic techniques to study a specific lncRNA called Pnky, which has been shown to regulate neural stem cells and influence neuronal production. By exploring how lncRNAs function at a molecular level, the research aims to uncover critical insights into brain development and the mechanisms underlying neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with neurological disorders unrelated to Alzheimer's or those without any cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the role of lncRNAs in various neurological disorders, indicating that this approach has potential for success.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Lim, Daniel a — University of California, San Francisco
- Study coordinator: Lim, Daniel a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.