Investigating long non-coding RNAs in cancers lacking the PTEN gene
Exploration of long non-coding RNAs as synthetic essential targets in Pten-deficient cancers
This study is looking at how certain molecules in our cells, called long non-coding RNAs, can influence cancer behavior in patients whose tumors have lost a key gene called PTEN, with the hope of finding new ways to treat these cancers.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10925237 on NIH RePORTER |
What this research studies
This research explores the role of long non-coding RNAs in cancers that have lost the PTEN tumor suppressor gene. It focuses on how these RNAs can affect cancer cell behavior by inhibiting certain proteins that are involved in cell growth and death. By studying the interactions between these non-coding RNAs and histone acetylation, the research aims to uncover new therapeutic targets for treating PTEN-deficient cancers. Patients may benefit from insights that could lead to innovative treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with cancers that exhibit PTEN loss.
Not a fit: Patients whose cancers do not involve PTEN deficiency may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with PTEN-deficient cancers.
How similar studies have performed: While the exploration of long non-coding RNAs is a growing field, this specific approach targeting PTEN-deficient cancers is relatively novel.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Chen, Jasper R — University of Tx Md Anderson Can Ctr
- Study coordinator: Chen, Jasper R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.