Investigating liver injury caused by COVID-19
Endotheliopathy and liver injury in COVID-19
This study is looking at how COVID-19 can harm the liver, especially in patients with severe symptoms, by checking blood and liver samples to see how inflammation and blood clotting are connected to liver damage.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10662455 on NIH RePORTER |
What this research studies
This research focuses on understanding how COVID-19 affects the liver, particularly through a condition called endotheliopathy, which leads to inflammation and blood clotting issues. By examining blood and liver tissue samples from COVID-19 patients, the researchers aim to uncover the mechanisms behind liver injury associated with the virus. The study will analyze the levels of proinflammatory cytokines, like IL-6, and their relationship to liver damage. Patients with severe COVID-19 symptoms may provide critical insights into this complex disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with COVID-19 who are experiencing liver injury or related complications.
Not a fit: Patients with mild COVID-19 symptoms or those without any liver injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver injury in COVID-19 patients, potentially reducing morbidity and mortality.
How similar studies have performed: Other research has indicated that understanding the mechanisms of COVID-19-related complications can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Iwakiri, Yasuko — Yale University
- Study coordinator: Iwakiri, Yasuko
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.