Investigating liver injury and fibrosis related to intestinal resection
Intestinal Resection Associated Liver Injury and Fibrosis
This study is looking at how surgery for short gut syndrome affects the liver in both kids and adults, especially when they rely on special nutrition through an IV, to find better ways to prevent liver damage and improve health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10902103 on NIH RePORTER |
What this research studies
This research focuses on understanding how intestinal resection, often necessary for treating short gut syndrome (SGS), leads to liver injury and fibrosis. It examines the unique biological responses in both children and adults who have undergone this procedure, particularly how their bodies react to parenteral nutrition. By using a mouse model, the study aims to uncover the mechanisms behind liver damage and the potential for developing advanced liver disease. The findings could help identify new treatment strategies to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and adults diagnosed with short gut syndrome who are experiencing liver complications.
Not a fit: Patients who do not have short gut syndrome or related liver conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for liver injury in patients with short gut syndrome, potentially reducing the need for liver transplants.
How similar studies have performed: Previous research has shown promising results in understanding liver injury mechanisms in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Warner, Brad Wayne — Washington University
- Study coordinator: Warner, Brad Wayne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.