Investigating liver health in women with HIV and latent tuberculosis
Biomarkers of Hepatotoxicity in Women Living with HIV and Latent TB
This study is looking at how safe and effective a medication called isoniazid is for pregnant and new moms living with HIV and latent tuberculosis, to help protect them from getting active TB while keeping their health in mind.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10823227 on NIH RePORTER |
What this research studies
This research focuses on pregnant and postpartum women living with HIV and latent tuberculosis infection, who are at a higher risk of developing active TB. It aims to understand the safety and effectiveness of isoniazid preventive therapy (IPT) during this critical period, particularly looking at how the body processes this medication and the potential for liver damage. By analyzing existing samples from previous studies, the research will explore the pharmacokinetics, immunologic, and metabolic changes that may affect these women. The goal is to provide insights that can help ensure safer treatment options for this vulnerable population.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant or postpartum women who are living with HIV and have been diagnosed with latent tuberculosis infection.
Not a fit: Patients who are not pregnant or postpartum, or those who do not have HIV or latent tuberculosis infection, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment protocols for pregnant and postpartum women living with HIV and latent TB, ultimately reducing the risk of severe liver damage and improving maternal and infant health outcomes.
How similar studies have performed: Previous studies have indicated high rates of hepatotoxicity in similar populations, highlighting the need for further investigation into safe treatment practices.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Brooks, Kristina Marie — University of Colorado Denver
- Study coordinator: Brooks, Kristina Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.