Investigating liver dysfunction caused by non-alcoholic steatohepatitis using bioengineered technology
Ex-vivo bioengineered technology to unravel dysfunction due to non-alcoholic steatohepatitis (NASH)
['FUNDING_R01'] · UNIVERSITY OF ARIZONA · NIH-11085912
This study is looking at a serious liver condition called NASH by taking blood from patients and turning it into liver-like cells to better understand how the disease works and find new ways to treat it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ARIZONA (nih funded) |
| Locations | 1 site (TUCSON, UNITED STATES) |
| Trial ID | NIH-11085912 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding non-alcoholic steatohepatitis (NASH), a severe liver condition that can lead to liver transplantation. By using a novel approach, the study will collect peripheral blood from patients with NASH and convert these cells into induced pluripotent stem cells (iPSCs). These iPSCs will then be transformed into liver-like cells to explore how different factors affect liver metabolism in a controlled environment. This method aims to provide insights into disease progression and potential treatments without the complications of traditional methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with non-alcoholic steatohepatitis or end-stage liver disease requiring transplantation.
Not a fit: Patients with liver diseases unrelated to non-alcoholic steatohepatitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments for NASH and improve patient outcomes.
How similar studies have performed: Other research has shown promise in using bioengineered systems to study liver diseases, indicating that this approach may yield valuable insights.
Where this research is happening
TUCSON, UNITED STATES
- UNIVERSITY OF ARIZONA — TUCSON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WERTHEIM, JASON A — UNIVERSITY OF ARIZONA
- Study coordinator: WERTHEIM, JASON A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.