Investigating liver diseases related to bile acids and sphingolipids
Official title: BLR&D Research Career Scientist Award Application
Funded at VA Veterans Administration Hospital · NIH-10951538 · Data updated 2026-11-12
This study is looking at how certain substances in the body, like bile acids and sphingolipids, impact liver health and diseases, especially for people with alcoholic liver disease and non-alcoholic fatty liver disease, to help find better ways to diagnose and treat these conditions for everyone, including Veterans.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA Veterans Administration Hospital NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project start | October 1, 2018 |
| Project end | September 30, 2028 |
| Funding year | 2025 |
| NIH project number | 5IK6BX004477-07 |
| Project ID | NIH-10951538 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from chronic liver diseases, particularly those related to alcohol consumption or metabolic disorders.
✕Less likely to help
Patients with acute liver conditions or those without liver disease may not benefit from this research.
What this research studies
This research focuses on understanding how bile acids and sphingolipids affect liver function and disease progression in conditions such as alcoholic liver disease and non-alcoholic fatty liver disease. By using advanced animal models, the research aims to uncover the complex signaling pathways involved in liver health and disease. The findings could lead to new diagnostic markers and treatments for chronic liver diseases, benefiting both Veterans and the general population.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments and better management strategies for chronic liver diseases.
How similar studies have gone: Previous research has shown promise in understanding liver diseases through similar signaling pathway investigations, indicating a potential for success in this area.
Where this research is happening
-
VA Veterans Administration Hospital
Richmond, United States Active
Researchers
- Principal investigator: Zhou, Huiping Rose — VA Veterans Administration Hospital
- Study coordinator: Zhou, Huiping Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.