Investigating liver cells in alcohol-related liver disease
Official title: "CYP1B1+PRRX1+NR4A2+ hepatic stellate cells in alcohol-associated hepatitis"
Funded at University of Southern California · NIH-10938555 · Data updated 2026-11-12
This study is looking at special liver cells to see how they affect alcohol-related liver disease, hoping to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 20, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $380,863 |
| NIH project number | 1R01AA031670-01 |
| Project ID | NIH-10938555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol-associated hepatitis, particularly those experiencing severe symptoms.
✕Less likely to help
Patients with liver diseases unrelated to alcohol consumption may not benefit from this research.
What this research studies
This research focuses on understanding the role of specific liver cells, known as hepatic stellate cells, in the progression of alcohol-associated hepatitis, a severe liver condition. By analyzing these cells in patients and using advanced genetic techniques, the study aims to identify different subsets of these cells that may contribute to liver inflammation and fibrosis. The researchers will explore how these cells behave in the context of chronic alcohol consumption and liver damage, potentially leading to new insights into treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from alcohol-associated hepatitis.
How similar studies have gone: Previous research has shown promising results in understanding liver cell behavior in other liver diseases, suggesting potential for success in this area as well.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Tsukamoto, Hidekazu — University of Southern California
- Study coordinator: Tsukamoto, Hidekazu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.