Investigating lipoproteins and cardiovascular disease risk in diabetes
Project 4: Lipoproteins and CVD risk in diabetes
['FUNDING_P01'] · UNIVERSITY OF WASHINGTON · NIH-10874527
This study is looking at how certain fats in your blood can affect heart disease risk for people with diabetes, especially focusing on good cholesterol and how it helps clear out bad cholesterol from your arteries, with the hope of finding ways to lower heart disease risk for those living with diabetes.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10874527 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how certain lipoproteins contribute to the risk of cardiovascular disease (CVD) in individuals with diabetes. By identifying specific proteins and lipoproteins that predict CVD risk in humans, the researchers conduct mechanistic studies in mice to explore these relationships further. The study emphasizes the role of high-density lipoproteins (HDL) and their ability to remove cholesterol from artery walls, particularly in patients with type 1 and type 2 diabetes. The goal is to uncover modifiable factors that could help reduce CVD risk in diabetic patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with type 1 or type 2 diabetes who are at risk for cardiovascular disease.
Not a fit: Patients without diabetes or those who do not have cardiovascular disease risk factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cardiovascular disease in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding lipoprotein profiles and their impact on cardiovascular health, indicating that this approach has potential for success.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HEINECKE, JAY W — UNIVERSITY OF WASHINGTON
- Study coordinator: HEINECKE, JAY W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus