Investigating lipid mediators to protect the brain after a stroke
Neuroprotective lipid mediators target penumbra in experimental ischemic stroke
This study is looking at how special fats called elovanoids can help protect brain cells and improve recovery after a stroke, and it's designed for people who want to learn about new ways to support brain health after such an event.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lsu Health Sciences Center NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project ID | NIH-10941655 on NIH RePORTER |
What this research studies
This research focuses on the use of elovanoids, which are specialized lipid molecules derived from fatty acids, to protect brain cells in the area surrounding a stroke. The study aims to understand how these elovanoids can promote cell survival and restore brain function after ischemic stroke by targeting specific genes in brain cells. Researchers will use advanced techniques, including MRI and gene sequencing, to assess the effects of these lipid mediators on brain health in a rat model of stroke. The ultimate goal is to develop a new therapeutic approach that enhances recovery and reduces disability after a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an ischemic stroke and are seeking innovative treatment options.
Not a fit: Patients who have not had a stroke or those with hemorrhagic stroke may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery outcomes for stroke patients.
How similar studies have performed: Previous research has shown promising results with similar lipid-based approaches in animal models, indicating potential for success in this novel application.
Where this research is happening
New Orleans, United States
- Lsu Health Sciences Center — New Orleans, United States (Active)
Researchers
- Principal investigator: Bazan, Nicolas G. — Lsu Health Sciences Center
- Study coordinator: Bazan, Nicolas G.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.