Investigating lipid changes in children's brain injuries
Official title: Oxidative Lipidomics in Pediatric Traumatic Brain Injury
Funded at Columbia University Health Sciences · NIH-10899048 · Data updated 2026-11-12
This study is looking at how certain changes in the body after a serious brain injury in kids can cause damage and affect recovery, with the goal of finding new treatments to help them heal better and think more clearly.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $317,067 |
| NIH project number | 5R37NS061817-14 |
| Project ID | NIH-10899048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research are children aged 0-21 who have experienced severe traumatic brain injuries.
✕Less likely to help
Patients who have not experienced traumatic brain injuries or are over the age of 21 may not receive benefit from this research.
What this research studies
This research focuses on understanding the role of oxidative stress and lipid peroxidation in pediatric traumatic brain injury (TBI). It aims to identify specific biochemical pathways that lead to neuronal damage and poor outcomes in children after severe TBI. By studying the effects of certain enzymes and lipid molecules, the research seeks to develop targeted therapies that could improve recovery and cognitive function in affected children. The approach includes both laboratory experiments and potential clinical applications based on findings from animal models.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery outcomes for children suffering from traumatic brain injuries.
How similar studies have gone: Previous research has shown that targeting specific biochemical pathways in brain injuries can lead to improved outcomes, suggesting that this approach may hold promise.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Bayir, Hülya — Columbia University Health Sciences
- Study coordinator: Bayir, Hülya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.