Investigating lipid changes in Alzheimer's disease
Acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease
This study is looking at how fats in the brain might play a role in Alzheimer's disease, and it aims to understand the differences in these fats between healthy brains and those affected by the disease, especially in people who may be at higher risk due to their genetics.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11103389 on NIH RePORTER |
What this research studies
This research explores how changes in lipid composition in the brain may contribute to the development and progression of Alzheimer's disease. By using advanced imaging techniques, the study examines specific brain regions to identify differences in lipid levels between healthy and Alzheimer's-affected brains. The research also investigates the role of certain enzymes in lipid metabolism and how these may be linked to the disease, particularly in individuals with genetic risk factors. Patients may be involved in providing biological samples or participating in related assessments.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals at risk for Alzheimer's disease, particularly those with genetic factors such as the ApoE4 variant.
Not a fit: Patients with advanced Alzheimer's disease or those without any genetic risk factors for the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Alzheimer's disease and potentially identify new therapeutic targets.
How similar studies have performed: Previous research has shown promising results in understanding lipid metabolism's role in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Mcintire, Laura Beth Johnson — Weill Medical Coll of Cornell Univ
- Study coordinator: Mcintire, Laura Beth Johnson
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.