Investigating learning differences in mice with autism risk genes
Official title: Strengths and weaknesses in learning in mice with ASD risk genes
Funded at University of California Berkeley · NIH-11080770 · Data updated 2026-11-12
This study is looking at how certain genetic differences related to autism spectrum disorder (ASD) affect learning and social behaviors in mice, which could help us understand more about the condition and find new ways to help those with ASD.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $507,215 |
| NIH project number | 5R01MH134514-03 |
| Project ID | NIH-11080770 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with autism spectrum disorder or those with a family history of ASD.
✕Less likely to help
Patients without autism spectrum disorder or those not genetically predisposed to ASD may not receive any benefit from this research.
What this research studies
This research explores how specific genetic differences associated with autism spectrum disorder (ASD) affect learning behaviors in mice. By studying mice with mutations in the Tsc2 gene, the researchers aim to understand how these genetic factors influence motor learning and social communication. The study will involve observing changes in brain circuits and behaviors that are relevant to ASD, providing insights into the underlying mechanisms of the disorder. The findings could help identify potential targets for therapeutic interventions.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for individuals with autism spectrum disorder.
How similar studies have gone: Previous research has shown promising results in understanding autism-related behaviors through genetic studies in animal models, indicating that this approach has potential for success.
Where this research is happening
-
University of California Berkeley
Berkeley, United States Active
Researchers
- Principal investigator: Wilbrecht, Linda E — University of California Berkeley
- Study coordinator: Wilbrecht, Linda E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.