Investigating kidney injury caused by environmental and therapeutic agents
Mitochondrial and Cellular Biomarkers of Renal Injury from Environmental and Therapeutic Agents
This study is looking at how certain environmental pollutants and medications can harm your kidneys, and it aims to find early warning signs of kidney damage using human kidney cells, which could help improve care for people at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10762966 on NIH RePORTER |
What this research studies
This research focuses on understanding how exposure to various environmental contaminants and therapeutic drugs can lead to kidney injury. By using human kidney cell cultures, the study aims to identify new biomarkers that can indicate kidney damage before it becomes severe. The approach involves examining changes in mitochondria and other cellular components to discover proteins and metabolites that signal early kidney injury. This could lead to better monitoring and treatment options for patients at risk of kidney damage.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals exposed to environmental toxins or those undergoing treatment with nephrotoxic therapeutic agents.
Not a fit: Patients with no history of exposure to environmental toxins or those not receiving nephrotoxic medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers that allow for earlier detection and intervention in kidney injury.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for kidney injury, but this approach focusing on mitochondrial dysfunction is relatively novel.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: Lash, Lawrence H. — Wayne State University
- Study coordinator: Lash, Lawrence H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.