Investigating kidney diseases using advanced microphysiological systems
Safety and Efficacy of Human Clinical Trials Using Kidney-on-a-Chip Microphysiological Systems
['FUNDING_OTHER'] · UNIVERSITY OF WASHINGTON · NIH-10894162
This study is working on a special mini kidney model to help us learn more about kidney diseases like Autosomal Dominant Polycystic Kidney Disease (ADPKD), using real human kidney cells, so we can find better treatments that might help patients in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10894162 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative 'kidney-on-a-chip' systems to better understand and model kidney diseases, particularly Autosomal Dominant Polycystic Kidney Disease (ADPKD). By utilizing human kidney cells derived from patients and advanced techniques like CRISPR gene editing, the study aims to create realistic models that mimic kidney function and disease processes. This approach allows researchers to explore the complexities of kidney diseases in a controlled environment, potentially leading to more effective treatments. Patients may benefit from insights gained through these models that could inform future clinical trials and therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Autosomal Dominant Polycystic Kidney Disease or other kidney-related conditions.
Not a fit: Patients with acute kidney injuries or those without chronic kidney disease may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and better management strategies for patients with kidney diseases.
How similar studies have performed: Previous research using microphysiological systems has shown promise in other areas, indicating potential for success in this novel application for kidney diseases.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FREEDMAN, BENJAMIN SOLOMON — UNIVERSITY OF WASHINGTON
- Study coordinator: FREEDMAN, BENJAMIN SOLOMON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease