Investigating kidney damage in a common genetic kidney disease.
Official title: Kidney Tubular Damage and Dysfunction in Autosomal Dominant Polycystic Kidney Disease
Funded at University of California, San Diego · NIH-11099913 · Data updated 2026-11-12
This study is looking for new ways to spot kidney damage earlier in people with autosomal dominant polycystic kidney disease (ADPKD) so that doctors can better tailor treatments for those who need them most.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $690,154 |
| NIH project number | 5R01DK139291-02 |
| Project ID | NIH-11099913 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autosomal dominant polycystic kidney disease.
✕Less likely to help
Patients without a diagnosis of autosomal dominant polycystic kidney disease or those with other unrelated kidney conditions may not benefit from this research.
What this research studies
This research focuses on autosomal dominant polycystic kidney disease (ADPKD), a genetic condition that leads to the growth of cysts in the kidneys, causing damage over time. The study aims to identify novel biomarkers that can help detect kidney damage earlier and assess the risk of disease progression. By analyzing kidney tubule health, the researchers hope to improve targeted treatments for patients at the highest risk and enhance clinical trial designs. This approach seeks to provide a better understanding of kidney function in ADPKD patients, which has not been thoroughly explored in previous studies.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective treatments for patients with ADPKD, potentially slowing disease progression.
How similar studies have gone: Previous research has shown promise in using biomarkers to assess kidney health in other conditions, suggesting potential success for this novel approach in ADPKD.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Garimella, Pranav — University of California, San Diego
- Study coordinator: Garimella, Pranav
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.