Investigating key genes and proteins in Alzheimer's patients with unusual brain changes
Identify and study the roles of key genes and proteins in subpopulations of Alzheimer's disease patients with uncoupled neurofibrillary tangles
This study is looking at how certain genes and proteins affect people with Alzheimer's who have unusual brain changes, to help understand why some people decline faster than others, with the hope of finding better ways to slow down memory loss.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10525012 on NIH RePORTER |
What this research studies
This research focuses on understanding the roles of specific genes and proteins in different groups of Alzheimer's disease patients who show unusual patterns of neurofibrillary tangles in their brains. By examining brain samples from these patients, the researchers aim to uncover why some individuals experience significant cognitive decline despite having high levels of neurofibrillary tangles, while others do not. The study employs advanced techniques in transcriptomics and proteomics to analyze the molecular differences in these subpopulations. The goal is to enhance precision medicine approaches for Alzheimer's and identify potential strategies to slow cognitive decline.
Who could benefit from this research
Good fit: Ideal candidates for this research include Alzheimer's disease patients, particularly those with atypical presentations of neurofibrillary tangles and cognitive impairment.
Not a fit: Patients with early-stage Alzheimer's disease who do not exhibit atypical neurofibrillary tangle patterns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that better address the diverse experiences of Alzheimer's patients.
How similar studies have performed: While research on Alzheimer's disease is extensive, this specific focus on atypical subpopulations and their molecular characteristics is relatively novel.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Zhang, Jie — Indiana University Indianapolis
- Study coordinator: Zhang, Jie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.