Investigating inherited genetic variants that increase the risk of glioma
Discovery, Biology and Risk of Inherited Variants in Glioma
This study is looking at how certain genes, especially the POT1 gene, might increase the risk of glioma, a type of brain tumor, by examining the DNA of families who have had this cancer, so that people with a family history of glioma can get better advice and support.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10834728 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to the development of glioma, a type of brain tumor. By analyzing the genomes of families with a history of glioma, the researchers aim to identify specific genetic mutations, particularly in the POT1 gene, that may increase the risk of this cancer. The study employs advanced genomic techniques, including whole genome sequencing, to discover new gene candidates and assess their potential role in glioma. Patients with a family history of glioma may benefit from insights gained through this research, which could lead to improved genetic counseling and targeted surveillance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of glioma, particularly those with multiple affected relatives.
Not a fit: Patients without a family history of glioma or those with sporadic cases of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of glioma risk for patients with a family history of the disease.
How similar studies have performed: Previous research has successfully identified genetic mutations associated with other cancers, suggesting that this approach may yield valuable insights for glioma as well.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Bondy, Melissa L. — Stanford University
- Study coordinator: Bondy, Melissa L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.