Investigating inflammation's role in liver cancer for better early detection and prevention.
Inflammation and Hepatocellular Carcinoma: A Multiomics Approach to Improve Early Detection, Causal Inference, and Lifestyle Based Prevention
['FUNDING_CAREER'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-11034190
This study is looking at how long-term inflammation might lead to liver cancer, and it's for people who want to understand more about the disease; researchers are comparing blood samples from liver cancer patients and healthy people to find clues that could help catch the cancer early and suggest ways to lower the risk for those who might be more likely to get it.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11034190 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how chronic inflammation contributes to hepatocellular carcinoma (HCC), a deadly form of liver cancer. By analyzing molecular data from various population cohorts, the study aims to identify specific protein signatures that can help in the early detection of HCC. The approach includes using advanced computational and systems biology techniques to compare the blood samples of HCC patients with those of healthy individuals. The ultimate goal is to improve risk assessment and develop lifestyle-based prevention strategies for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high risk for liver cancer, particularly those with chronic liver disease or inflammation.
Not a fit: Patients with no history of liver disease or those who are not at risk for hepatocellular carcinoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of liver cancer, potentially improving survival rates and treatment outcomes for patients.
How similar studies have performed: Previous research has shown promise in using molecular signatures for cancer detection, indicating that this approach could yield significant insights.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZHANG, XINYUAN — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: ZHANG, XINYUAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.