Investigating inflammation's role in brain hemorrhage recovery
CAPSTONE: Central And Peripheral STrOke inflammatioN with Exosomes
['FUNDING_R01'] · UNIVERSITY OF CINCINNATI · NIH-10866504
This study is looking at how inflammation impacts recovery after a serious brain bleed, and it’s for people who have survived this condition; by examining tiny particles in the blood, researchers hope to find out more about how inflammation affects thinking and memory, which could help improve treatments for survivors.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CINCINNATI (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-10866504 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how inflammation affects recovery after intracerebral hemorrhage (ICH), a serious brain condition. By analyzing exosomes—tiny vesicles released from brain cells in the blood—the study aims to uncover the mechanisms behind cognitive decline in ICH survivors. The research will involve collecting blood samples from 250 participants over time to assess inflammatory markers and their relationship to recovery outcomes. This approach could lead to better insights into treatment options for those affected by ICH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced an intracerebral hemorrhage, particularly those from ethnic/racial minority groups.
Not a fit: Patients who have not experienced an intracerebral hemorrhage or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients recovering from brain hemorrhages.
How similar studies have performed: Previous research has shown promising results in understanding inflammation's role in brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
CINCINNATI, UNITED STATES
- UNIVERSITY OF CINCINNATI — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WALSH, KYLE BRENDAN — UNIVERSITY OF CINCINNATI
- Study coordinator: WALSH, KYLE BRENDAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury