Investigating inflammation in the eyes of diabetic patients
Microglia Mediated Inflammation in the Diabetic Retina
['FUNDING_R01'] · UNIVERSITY OF TEXAS SAN ANTONIO · NIH-10460458
This study is looking at how inflammation in the eye affects people with diabetes, using mice to learn more about a specific pathway that might help protect vision and manage eye problems related to diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TEXAS SAN ANTONIO (nih funded) |
| Locations | 1 site (SAN ANTONIO, UNITED STATES) |
| Trial ID | NIH-10460458 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how inflammation in the retina affects individuals with diabetes. It examines the role of a specific signaling pathway involving fractalkine and its receptor, which may influence the activation of immune cells called microglia. By using mouse models that mimic human diabetes, the study aims to uncover the mechanisms behind retinal damage and inflammation, potentially leading to new therapeutic strategies for diabetic retinopathy. Patients may benefit from insights gained about how to protect their vision and manage inflammation related to diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with diabetes, particularly those experiencing or at risk for diabetic retinopathy.
Not a fit: Patients without diabetes or those who do not have any retinal complications related to diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that protect the retina from damage caused by diabetes, improving vision and quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in diabetic retinopathy, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN ANTONIO, UNITED STATES
- UNIVERSITY OF TEXAS SAN ANTONIO — SAN ANTONIO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARDONA, ASTRID E — UNIVERSITY OF TEXAS SAN ANTONIO
- Study coordinator: CARDONA, ASTRID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.