Investigating inflammation in sickle cell disease
Inflammatory caspase activation in sickle cell disease
This study is looking at how long-lasting inflammation impacts kids with sickle cell disease and aims to find new ways to reduce this inflammation and help them feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11056758 on NIH RePORTER |
What this research studies
This research focuses on understanding how chronic inflammation affects children with sickle cell disease (SCD). It aims to identify the mechanisms by which heme, released during red blood cell breakdown, activates inflammatory proteins called caspases, particularly caspase-4. By exploring these processes, the research seeks to uncover new treatment targets that could help reduce inflammation and improve clinical outcomes for patients suffering from SCD-related complications.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with sickle cell disease.
Not a fit: Patients who are not diagnosed with sickle cell disease or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that effectively manage inflammation in sickle cell disease, potentially reducing severe complications.
How similar studies have performed: Previous research has shown promise in targeting inflammatory pathways in sickle cell disease, suggesting that this approach could yield beneficial results.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Bouchier-Hayes, Lisa — Baylor College of Medicine
- Study coordinator: Bouchier-Hayes, Lisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.