Investigating inflammation biomarkers in knee osteoarthritis
Official title: MR Biomarkers of Inflammation in Knee Osteoarthritis
Funded at VA San Diego Healthcare System · NIH-10975383 · Data updated 2026-11-12
This study is looking at how inflammation affects knee pain and movement in military service members and Veterans with osteoarthritis, hoping to find new ways to help manage their pain and improve their knee function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX000625-11 |
| Project ID | NIH-10975383 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military service members and Veterans suffering from knee osteoarthritis, particularly those with a history of joint trauma.
✕Less likely to help
Patients with knee osteoarthritis not related to trauma or those without significant inflammatory components may not benefit from this research.
What this research studies
This research focuses on understanding the role of inflammation in knee osteoarthritis (OA), particularly in military service members and Veterans who are at higher risk due to joint trauma. The study aims to identify specific biomarkers that indicate inflammation and how these relate to pain and functional decline in patients with post-traumatic osteoarthritis. By utilizing advanced MRI techniques, the research seeks to correlate structural changes in the knee with inflammatory processes, potentially leading to new treatment strategies. The ultimate goal is to improve pain management and joint function for those affected by this condition.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted treatments that alleviate pain and improve mobility for patients with knee osteoarthritis.
How similar studies have gone: Previous research has shown promise in identifying biomarkers related to inflammation in osteoarthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Chung, Christine B — VA San Diego Healthcare System
- Study coordinator: Chung, Christine B
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.