Investigating inflammation and iron buildup in frontotemporal dementia
Official title: Glial-mediated Inflammation and Iron Accumulation in Frontotemporal Dementia
Funded at University of Pennsylvania · NIH-11022104 · Data updated 2026-11-12
This study is looking at how inflammation and iron build-up in the brains of people with frontotemporal dementia might affect their condition, with the hope of finding better ways to diagnose and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 15, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $803,111 |
| NIH project number | 1R01AG090414-01 |
| Project ID | NIH-11022104 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with frontotemporal dementia, particularly those under 65 years of age.
✕Less likely to help
Patients with other forms of dementia, such as Alzheimer's disease, may not receive direct benefits from this research.
What this research studies
This research aims to explore the progression of neuroinflammation and iron accumulation in the brains of patients with frontotemporal dementia (FTD). By examining brain tissue from individuals with different types of FTD pathology, the study seeks to understand how these factors contribute to neurodegeneration. The approach includes advanced imaging techniques and detailed cellular analysis to identify patterns that could lead to better diagnostic methods and potential therapies. Patients with FTD may benefit from insights gained about their condition and future treatment options.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for frontotemporal dementia.
How similar studies have gone: While research on frontotemporal dementia is limited, similar studies on neuroinflammation and iron accumulation in other neurodegenerative diseases have shown promising results.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Irwin, David John — University of Pennsylvania
- Study coordinator: Irwin, David John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.