Investigating inflammation and brain changes in aging and Alzheimer's disease
Biomarkers of Inflammation, Neurodegeneration and Age-Associated Cognitive Impairment
This study is looking at how inflammation in the brain might affect thinking and memory as we age, using monkeys that age like us to help find early signs of problems that could lead to better ways to spot and treat conditions like Alzheimer's.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10898825 on NIH RePORTER |
What this research studies
This research focuses on understanding how inflammation in the brain may contribute to cognitive decline and neurodegenerative diseases like Alzheimer's. By studying rhesus macaques, which age similarly to humans, researchers will examine the relationship between neuroinflammatory markers, brain structure, and cognitive function. The study employs advanced techniques such as protein biomarker assays and imaging to gather detailed insights into these processes. This approach aims to identify early indicators of cognitive impairment that could lead to better screening and treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults experiencing cognitive decline or those at risk for Alzheimer's disease.
Not a fit: Patients with cognitive impairment due to non-age-related factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment strategies for cognitive decline and Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in understanding neuroinflammation's role in cognitive decline, suggesting this approach could yield valuable insights.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Weiss, Alison Ruth — Oregon Health & Science University
- Study coordinator: Weiss, Alison Ruth
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.