Investigating infections related to heart devices caused by Staphylococcus aureus
Staphylococcus aureus Cardiac Device Infections - From the Vascular Viewpoint
This study is looking at patients with serious heart problems who have devices implanted in their hearts, to find early signs that could help predict if they might get an infection from a common bacteria, so we can improve how we diagnose and treat these infections and help keep patients healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10843828 on NIH RePORTER |
What this research studies
This research focuses on patients with advanced cardiovascular disease who have implanted cardiac devices, which can improve their survival but also pose a risk of infection. The study aims to identify early biomarkers that indicate the risk of developing a cardiac device infection (CDI) caused by Staphylococcus aureus. By utilizing a unique biorepository and advanced biological models, researchers will explore why some patients develop these infections while others do not. The goal is to enhance early diagnosis and treatment, potentially saving lives and improving patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with advanced cardiovascular disease who have implanted cardiac devices and are at risk for Staphylococcus aureus infections.
Not a fit: Patients without implanted cardiac devices or those not at risk for Staphylococcus aureus infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and treatment of cardiac device infections, significantly reducing complications and mortality rates.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for infections, suggesting that this approach may lead to significant advancements in the field.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Maskarinec, Stacey a — Duke University
- Study coordinator: Maskarinec, Stacey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.