Investigating immune system issues and inflammation in cystic fibrosis
Innate Immune Defect and Neutrophilic Inflammation in Cystic Fibrosis
['FUNDING_R01'] · LSU HEALTH SCIENCES CENTER · NIH-10672206
This study is looking at how problems with the immune system can cause lung inflammation in people with cystic fibrosis, focusing on a key gene called CFTR, to help find new ways to improve treatment for those affected.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LSU HEALTH SCIENCES CENTER (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-10672206 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how defects in the immune system contribute to lung inflammation in cystic fibrosis (CF). It aims to explore the role of a specific gene, CFTR, which is crucial for lung function and immune response. By examining how the loss of function of this gene affects immune cells, the research seeks to uncover the mechanisms behind chronic inflammation and bacterial infections in CF patients. The findings could lead to new insights into potential therapies that target these immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis, particularly those experiencing chronic lung inflammation and infections.
Not a fit: Patients without cystic fibrosis or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce lung inflammation and enhance the quality of life for cystic fibrosis patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in cystic fibrosis, but this specific approach is novel and aims to fill critical knowledge gaps.
Where this research is happening
NEW ORLEANS, UNITED STATES
- LSU HEALTH SCIENCES CENTER — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WANG, GUOSHUN — LSU HEALTH SCIENCES CENTER
- Study coordinator: WANG, GUOSHUN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.