Investigating immune signaling at synapses in Alzheimer's disease
Innate immune signaling at the synapse in development and pathological Alzheimer’s disease
This study is looking at how the immune system affects brain connections in people with Alzheimer's, and it aims to find ways to protect memory by blocking certain immune signals, which could help those dealing with memory loss from the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10763392 on NIH RePORTER |
What this research studies
This research explores how immune signaling at synapses may contribute to the development of Alzheimer's disease. It focuses on the role of specific immune molecules in synapse pruning, which is the process of eliminating weaker synapses during brain development and potentially in Alzheimer's pathology. By studying genetically modified mice, the researchers aim to understand how blocking certain immune receptors can protect against memory loss associated with Alzheimer's, even in the presence of harmful beta amyloid plaques. This approach could lead to new therapeutic strategies for preserving memory function in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients with early-stage Alzheimer's disease who do not have significant synaptic loss may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent memory loss in Alzheimer's patients.
How similar studies have performed: Previous research has shown promising results in understanding immune signaling in neurodegenerative diseases, suggesting potential for success in this novel approach.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Shatz, Carla J — Stanford University
- Study coordinator: Shatz, Carla J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.