Investigating immune responses to SARS-CoV-2 in healthy and cancer patients
SARS-CoV-2-reactive tissue-resident memory T cells in healthy and cancer subjects
This study is looking at how certain immune cells in the body react to the COVID-19 virus in both healthy people and those with cancer, to help us understand how well these cells can protect against the virus and improve future vaccines.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10855009 on NIH RePORTER |
What this research studies
This research focuses on understanding how tissue-resident memory T cells respond to SARS-CoV-2 in both healthy individuals and cancer patients. By analyzing samples from a cohort of 200 participants, including 100 cancer patients and 100 healthy individuals, the study aims to uncover the role of these immune cells in providing protection against COVID-19. The researchers will utilize advanced techniques such as single-cell RNA sequencing to gain insights into the cellular immunity against the virus. This could help determine the durability of immune responses and inform future vaccine strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are either healthy or diagnosed with cancer, particularly those who have been exposed to SARS-CoV-2.
Not a fit: Patients who are not exposed to SARS-CoV-2 or those with conditions that severely compromise their immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of immune protection against COVID-19, potentially enhancing treatment and prevention strategies for patients.
How similar studies have performed: Previous research has shown promising results in understanding T cell responses to viral infections, indicating that this approach has potential for success.
Where this research is happening
La Jolla, United States
- La Jolla Institute for Immunology — La Jolla, United States (Active)
Researchers
- Principal investigator: Vijayanand, Pandurangan — La Jolla Institute for Immunology
- Study coordinator: Vijayanand, Pandurangan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.