Investigating immune responses to SARS-CoV-2 in healthy and cancer patients
SARS-CoV-2-reactive tissue-resident memory T cells in healthy and cancer subjects
This study is looking at how certain immune cells called tissue-resident memory T cells react to the virus that causes COVID-19 in both healthy people and those with cancer, to help us learn more about how our bodies fight off infections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10688355 on NIH RePORTER |
What this research studies
This research focuses on understanding how tissue-resident memory T cells respond to SARS-CoV-2 in both healthy individuals and cancer patients. The team will analyze immune responses by examining T cells from a cohort of 200 participants, split evenly between those with cancer and those without. Using advanced techniques like single-cell RNA sequencing, they aim to uncover how these immune cells function and their potential role in providing protection against COVID-19. This study seeks to enhance our understanding of cellular immunity in the context of viral infections and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are either healthy or diagnosed with cancer, particularly those who have been exposed to SARS-CoV-2.
Not a fit: Patients who are not exposed to SARS-CoV-2 or those with conditions that severely compromise their immune system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing immune responses against SARS-CoV-2, particularly in vulnerable cancer patients.
How similar studies have performed: Other research has shown promising results in understanding T cell responses to viral infections, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- La Jolla Institute for Immunology — La Jolla, United States (Active)
Researchers
- Principal investigator: Vijayanand, Pandurangan — La Jolla Institute for Immunology
- Study coordinator: Vijayanand, Pandurangan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.