Investigating immune responses to multidrug resistant Klebsiella pneumoniae infections
Official title: Project 1 McCombs
Funded at Tulane University of Louisiana · NIH-11017004 · Data updated 2026-11-12
This study is looking at how our immune system fights off a tough bacteria called Klebsiella pneumoniae, which can cause pneumonia in adults, and aims to find new ways to boost our immune response, especially since men and women may react differently, to help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tulane University of Louisiana NIH-funded |
| Lab location | 1 site (New Orleans, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $226,562 |
| NIH project number | 5P20GM152305-02 |
| Project ID | NIH-11017004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults who are at risk of or currently suffering from infections caused by multidrug resistant Klebsiella pneumoniae.
✕Less likely to help
Patients with infections caused by other pathogens or those who do not have a compromised immune response may not benefit from this research.
What this research studies
This research focuses on understanding how the immune system responds to multidrug resistant Klebsiella pneumoniae, a significant cause of hospital-acquired pneumonia in adults. The study aims to develop new therapeutic strategies that enhance the host's immune response, particularly considering the differences between male and female immune responses. By examining immune cell populations and their roles in fighting this infection, the research seeks to identify effective immunotherapies that could improve patient outcomes. The approach includes analyzing immune responses in animal models to inform potential treatments for humans.
Why it matters
Potential benefit: If successful, this research could lead to new immunotherapies that significantly improve treatment options for patients suffering from infections caused by multidrug resistant Klebsiella pneumoniae.
How similar studies have gone: Previous research has shown success in enhancing immune responses to other bacterial infections, suggesting that this approach may also be effective for Klebsiella pneumoniae.
Where this research is happening
-
Tulane University of Louisiana
New Orleans, United States Active
Researchers
- Principal investigator: Mccombs, Janet Elaine — Tulane University of Louisiana
- Study coordinator: Mccombs, Janet Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.