Investigating immune responses to influenza in humans and primates
Official title: Project 1: Human and Non-human Primate Influenza B-cell Repertoires
Funded at Boston Children's Hospital · NIH-11290938 · Data updated 2026-11-12
This study is looking at how our immune cells, called B-cells, fight off the flu virus in people and monkeys, with the goal of finding better ways to create vaccines and treatments for the flu.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $710,000 |
| NIH project number | 5P01AI089618-13 |
| Project ID | NIH-11290938 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation would include individuals with a history of influenza infections or those interested in vaccine development.
✕Less likely to help
Patients who are not affected by influenza or have no interest in vaccine-related research may not benefit from this research.
What this research studies
This research focuses on understanding the B-cell repertoires that respond to influenza viruses in both humans and non-human primates. By analyzing the immune responses, the study aims to identify how these immune cells recognize and combat influenza infections. The approach involves collecting and examining blood samples to assess the diversity and functionality of B-cells, which are crucial for producing antibodies against viruses. This research could lead to improved vaccine strategies and treatments for influenza.
Why it matters
Potential benefit: If successful, this research could enhance the development of more effective vaccines and therapies for influenza, potentially reducing the impact of the virus on patients.
How similar studies have gone: Previous research has shown promise in understanding immune responses to influenza, indicating that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Moody, Michael Anthony — Boston Children's Hospital
- Study coordinator: Moody, Michael Anthony
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.